Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888585 | 1.00 | LMNA (0.45) | LMNANOTUMIDH1ERCC1ERCC4 | |
| SCHEMBL9888714 | 0.87 | RXRA (0.47) | LMNANOTUMIDH1ERCC1ERCC4 | |
| SCHEMBL19732418 | 0.84 | NOTUM (0.42) | LMNANOTUMIDH1ERCC1ERCC4 | |
| SCHEMBL18793689 | 0.84 | NOTUM (0.42) | LMNANOTUMIDH1ERCC1ERCC4 | |
| SCHEMBL8215541 | 0.81 | NOTUM (0.55) | NOTUMKDM5BLRRK2POLBKDM4E | |
| SCHEMBL5567481 | 0.81 | NOTUM (0.55) | NOTUMKDM5BLRRK2POLBKDM4E | |
| SCHEMBL25611001 | 0.81 | MAPT (0.43) | LMNANOTUMIDH1ERCC1ERCC4 | |
| SCHEMBL5934873 | 0.78 | NOTUM (0.57) | LMNANOTUMERCC1ERCC4KDM4E | |
| SCHEMBL21583900 | 0.78 | LMNA (0.56) | LMNAERCC1ERCC4POLBMPO | |
| SCHEMBL5330796 | 0.77 | CYP2A6 (0.47) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |