Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | DRD3 | P35462 | 8/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20720388 | 0.82 | AKR1C3 (0.48) | MAPTDRD2DRD3AKR1C3AKR1C1 | |
| SCHEMBL2310030 | 0.81 | NOTUM (0.49) | MAPTDRD2DRD3AKR1C3AKR1C1 | |
| SCHEMBL29338249 | 0.78 | SLC6A15 (0.54) | MEN1 | |
| SCHEMBL1791230 | 0.77 | ESR1 (0.55) | MAPTDRD2DRD3AKR1C3AKR1C1 | |
| SCHEMBL28369820 | 0.77 | AKR1C3 (0.52) | MAPTDRD2DRD3AKR1C3AKR1C1 | |
| SCHEMBL29040775 | 0.77 | AKR1C3 (0.52) | MAPTDRD2DRD3AKR1C3AKR1C1 | |
| SCHEMBL10163702 | 0.75 | NOTUM (0.58) | MAPTDRD2DRD3AKR1C3DRD4 | |
| SCHEMBL29338289 | 0.74 | ESR1 (0.56) | DRD2DRD3MEN1DRD4ALDH1A1 | |
| SCHEMBL2123156 | 0.74 | ESR2 (0.57) | MAPTDRD2 | |
| SCHEMBL9590882 | 0.73 | SLC6A15 (0.74) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |