Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598291 | 1.00 | LDHA (0.55) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL5973191 | 1.00 | LDHA (0.55) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| Hydrochloric Acid SCHEMBL5973458 | 0.99 | LDHA (0.54) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| Hydrochloric Acid SCHEMBL5973459 | 0.99 | LDHA (0.54) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL23387524 | 0.87 | ALDH1A1 (0.63) | LDHAMEN1KMT2AALDH1A1PKM | |
| SCHEMBL15105327 | 0.87 | ALDH1A1 (0.63) | LDHAMEN1KMT2AALDH1A1PKM | |
| SCHEMBL30611530 | 0.87 | ALDH1A1 (0.63) | LDHAMEN1KMT2AALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL5369130 | 0.87 | LDHA (0.54) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL159000 | 0.86 | LDHA (0.73) | LDHASLC7A5PTGS1KDM4EUSP2 | |
| SCHEMBL159001 | 0.86 | LDHA (0.73) | LDHASLC7A5PTGS1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4364944-B2 | — | — | 2009-11-18 | — | — | JP | claimed |
| EP-0934065-B1 | NOVEL CRYPTOPHYCIN DERIVATIVES AS ANTI-NEOPLASTIC AGENTS | UNIV HAWAII (US) | 2006-06-07 | — | — | EP | claimed |
| US-6680311-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | ELI LILLY AND COMPANY | 2004-01-20 | — | — | US | claimed |
| JP-2002514175-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0934065-A4 | PHARMACEUTICAL COMPOUNDS | LILLY CO ELI (US) | 2000-10-11 | — | — | EP | claimed |
| EP-0934065-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998008505-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | claimed |
| US-20230303625-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | RA PHARMACEUTICALS, INC. (US) | 2023-09-28 | — | — | US | disclosed |
| US-11530244-B2 | Cyclic polypeptides for PCSK9 inhibition | MERCK SHARP & DOHME LLC (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210284694-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | MERCK SHARP & DOHME LLC | 2021-09-16 | — | — | US | disclosed |
| WO-2012025464-A1 | FLUORODEUTERIOMETHYL TYROSINE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-01 | — | — | WO | disclosed |
| EP-0934065-B1 | NOVEL CRYPTOPHYCIN DERIVATIVES AS ANTI-NEOPLASTIC AGENTS | UNIV HAWAII (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-0830136-B1 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIV HAWAII (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-1998008505-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0735819-A4 | NEW CRYPTOPHYCINS | UNIV HAWAII (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1996039829-A9 | NEW CRYPTOPHYCINS | — | 1997-02-20 | — | — | WO | disclosed |
| WO-1996040184-A1 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIVERSITY OF HAWAII (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996039829-A1 | NEW CRYPTOPHYCINS | UNIVERSITY OF HAWAII (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0735819-A1 | NEW CRYPTOPHYCINS | UNIVERSITY OF HAWAII (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017093-A1 | NEW CRYPTOPHYCINS | UNIVERSITY OF HAWAII (US) | 1995-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284694-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | PCSK9, LDLR, PCSK7 | LDHA 3590/4885SLC7A5 3660/4885PTGS1 4052/4885 |
| US-20230303625-A1 | CYCLIC POLYPEPTIDES FOR PCSK9 INHIBITION | PCSK9, LDLR, PCSK7 | LDHA 3590/4885SLC7A5 3660/4885PTGS1 4052/4885 |
| US-11530244-B2 | Cyclic polypeptides for PCSK9 inhibition | PCSK9, LDLR, PCSK7 | LDHA 3590/4885SLC7A5 3660/4885PTGS1 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.