Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.40 |
| ▸ | CFD | P00746 | 10/20 | 0.39 |
| ▸ | TPSB2 | P20231 | 7/20 | 0.39 |
| ▸ | F11 | P03951 | 6/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29339695 | 0.93 | CFD (0.39) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL29339698 | 0.93 | CFD (0.39) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL29340323 | 0.91 | CFD (0.42) | ICMTCFDP2RX3 | |
| SCHEMBL29339702 | 0.91 | CFD (0.40) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL29339704 | 0.90 | CFD (0.46) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL23218830 | 0.89 | CFD (0.42) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL29592627 | 0.89 | CFD (0.42) | ICMTCFDTPSB2F11PTGER1 | |
| SCHEMBL29339668 | 0.89 | ICMT (0.38) | ICMTCFDTPSB2F11PLG | |
| SCHEMBL31018914 | 0.88 | CFD (0.41) | ICMTCFDTPSB2F11PLG | |
| SCHEMBL29339676 | 0.88 | CFD (0.41) | ICMTCFDTPSB2F11PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239752-A1 | BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | KLK5, KLK1, KLKB1 | ICMT 4826/4885CFD 3529/4885TPSB2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.