Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35457 | 0.85 | HPGD (0.49) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL35456 | 0.85 | HPGD (0.49) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL935410 | 0.85 | HPGD (0.49) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL27608489 | 0.81 | GPR119 (0.54) | GPR119STSKDM4EMAPTTHRB | |
| SCHEMBL641613 | 0.77 | MEN1 (0.52) | USP30MAPT | |
| SCHEMBL192730 | 0.77 | MEN1 (0.52) | USP30MAPT | |
| SCHEMBL1992277 | 0.77 | MEN1 (0.52) | USP30MAPT | |
| SCHEMBL6497026 | 0.77 | USP30 (0.52) | GPR119USP30MAPT | |
| SCHEMBL227336 | 0.77 | HPGD (0.55) | GPR119KDM4EMAPTTHRBPTPN2 | |
| SCHEMBL16039992 | 0.76 | HPGD (0.52) | USP30PDE4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |