Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548746 | 0.91 | — | — | |
| SCHEMBL12233933 | 0.90 | — | — | |
| SCHEMBL2548747 | 0.88 | CTSL (0.30) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3770808 | 0.86 | — | — | |
| SCHEMBL2567032 | 0.79 | KCNN4 (0.33) | SMN1; SMN2 | |
| SCHEMBL2567029 | 0.79 | KCNN4 (0.33) | SMN1; SMN2 | |
| SCHEMBL2567035 | 0.79 | KCNN4 (0.33) | SMN1; SMN2 | |
| SCHEMBL13010742 | 0.79 | CACNA1G (0.32) | — | |
| SCHEMBL3210998 | 0.72 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3211002 | 0.72 | KMT2A (0.35) | KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440658-B2 | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2229368-A1 | CYCLIC UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009075835-A1 | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICAL, INC (US) | 2009-06-18 | — | — | WO | disclosed |