Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 15/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348117 | 0.92 | NLRP3 (0.46) | NLRP3AKR1B1MAPT | |
| SCHEMBL29348102 | 0.89 | NLRP3 (0.49) | NLRP3AKR1B1MAPT | |
| SCHEMBL24077187 | 0.83 | NLRP3 (0.53) | NLRP3AKR1B1MAPT | |
| SCHEMBL24076871 | 0.83 | NLRP3 (0.55) | NLRP3AKR1B1MAPT | |
| SCHEMBL24077256 | 0.82 | NLRP3 (0.62) | NLRP3AKR1B1 | |
| SCHEMBL24077348 | 0.82 | NLRP3 (0.57) | NLRP3AKR1B1MAPT | |
| SCHEMBL24077189 | 0.81 | NLRP3 (0.50) | NLRP3AKR1B1MAPT | |
| SCHEMBL24077172 | 0.81 | AKR1B1 (0.53) | NLRP3AKR1B1MAPT | |
| SCHEMBL24076374 | 0.81 | NLRP3 (0.54) | NLRP3AKR1B1 | |
| SCHEMBL24076329 | 0.81 | NLRP3 (0.51) | NLRP3AKR1B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | NLRP3, NLRP1, PYCARD | NLRP3 1/4885AKR1B1 320/4885MAPT 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.