⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348212 | 0.72 | P2RX7 (0.33) | — | |
| SCHEMBL29348211 | 0.68 | PIK3CD (0.34) | — | |
| SCHEMBL29349106 | 0.65 | — | — | |
| SCHEMBL29348209 | 0.65 | IDH1 (0.36) | — | |
| SCHEMBL12284503 | 0.64 | TOP2A (0.33) | — | |
| SCHEMBL29348842 | 0.63 | MAPK1 (0.41) | — | |
| SCHEMBL29348255 | 0.63 | — | — | |
| SCHEMBL19344899 | 0.63 | P2RX7 (0.34) | — | |
| SCHEMBL25099327 | 0.62 | CYP1A2 (0.31) | — | |
| SCHEMBL25100292 | 0.61 | IDH1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |