Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | BMP4 | P12644 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348368 | 0.92 | TNF (0.49) | CRBNESR1DRD2DDB1TNF | |
| SCHEMBL29348353 | 0.86 | TNF (0.41) | CRBNESR1DRD2DDB1TNF | |
| SCHEMBL29348358 | 0.84 | CRBN (0.50) | CRBNDRD2DDB1KMT2APDCD1LG2 | |
| SCHEMBL29348350 | 0.84 | CRBN (0.49) | CRBNDRD2DDB1KMT2APDCD1LG2 | |
| SCHEMBL29348367 | 0.83 | CRBN (0.47) | CRBNESR1DRD2DDB1KMT2A | |
| SCHEMBL31068149 | 0.81 | CRBN (0.46) | CRBNDDB1PDCD1LG2CD274 | |
| SCHEMBL29348386 | 0.81 | CRBN (0.46) | CRBNDDB1PDCD1LG2CD274 | |
| SCHEMBL29348414 | 0.81 | CRBN (0.46) | CRBNDRD2DDB1TNFPDCD1LG2 | |
| SCHEMBL31068109 | 0.81 | CRBN (0.46) | CRBNDDB1PDCD1LG2CD274 | |
| SCHEMBL29348439 | 0.81 | CRBN (0.46) | CRBNDDB1PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |