Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348368 | 0.88 | TNF (0.49) | TNFCRBNDDB1DRD2HRH3 | |
| SCHEMBL29348339 | 0.86 | CRBN (0.44) | TNFCD274PDCD1LG2CRBNDDB1 | |
| SCHEMBL29348350 | 0.82 | CRBN (0.49) | CD274PDCD1LG2CRBNDDB1DRD2 | |
| SCHEMBL29348358 | 0.80 | CRBN (0.50) | CD274PDCD1LG2CRBNDDB1DRD2 | |
| SCHEMBL29348367 | 0.79 | CRBN (0.47) | CD274PDCD1LG2CRBNDDB1DRD2 | |
| SCHEMBL29348356 | 0.79 | CRBN (0.44) | TNFCD274PDCD1LG2CRBNDDB1 | |
| SCHEMBL29348338 | 0.78 | PDE10A (0.48) | CRBNDDB1 | |
| SCHEMBL29348577 | 0.77 | CRBN (0.44) | CD274PDCD1LG2CRBNDDB1 | |
| SCHEMBL29348398 | 0.77 | CRBN (0.41) | TNFCD274PDCD1LG2CRBNDDB1 | |
| SCHEMBL31068109 | 0.77 | CRBN (0.46) | CD274PDCD1LG2CRBNDDB1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |