Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463126 | 0.86 | MET (0.42) | METKDRRETKITPDGFRA | |
| SCHEMBL2928469 | 0.84 | MET (0.49) | METKDRRETKITPDGFRA | |
| SCHEMBL2928468 | 0.84 | MET (0.49) | METKDRRETKITPDGFRA | |
| SCHEMBL3753851 | 0.84 | MET (0.49) | METKDRRETKITPDGFRA | |
| SCHEMBL30146837 | 0.84 | MET (0.49) | METKDRRETKITPDGFRA | |
| SCHEMBL1794175 | 0.84 | GRM4 (0.43) | METKDRRETKITPDGFRA | |
| SCHEMBL18256939 | 0.81 | MET (0.82) | METKDRRETKITPDGFRA | |
| SCHEMBL27171642 | 0.81 | MET (0.54) | METKDRRETKITPDGFRA | |
| SCHEMBL2928213 | 0.80 | PDGFRA (0.44) | METKDRKITPDGFRAFLT3 | |
| SCHEMBL1137330 | 0.80 | MET (0.73) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4339196-A1 | NOVEL UREA DERIVATIVE COMPOUND AS RON INHIBITOR | LG Chem, Ltd. (KR) | 2024-03-20 | — | — | EP | disclosed |
| EP-4339197-A1 | NOVEL UREA DERIVATIVE COMPOUND AS RON INHIBITOR | Lg Chem, Ltd. (KR) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022270980-A1 | NOVEL UREA DERIVATIVE COMPOUND AS RON INHIBITOR | 주식회사 엘지화학 | 2022-12-29 | — | — | WO | disclosed |
| WO-2022270979-A1 | NOVEL UREA DERIVATIVE COMPOUND AS RON INHIBITOR | 주식회사 엘지화학 | 2022-12-29 | — | — | WO | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |