Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928468 | 1.00 | MET (0.49) | METKDRRETKITPDGFRA | |
| SCHEMBL13610912 | 0.89 | MET (0.47) | METKDRRETKITPDGFRA | |
| SCHEMBL4464910 | 0.88 | SMN1; SMN2 (0.42) | METKDRRETKITPDGFRA | |
| SCHEMBL4464904 | 0.88 | SMN1; SMN2 (0.42) | METKDRRETKITPDGFRA | |
| SCHEMBL3762191 | 0.86 | MET (0.45) | METKDRRETKITPDGFRA | |
| SCHEMBL29988424 | 0.86 | MET (0.45) | METKDRRETKITPDGFRA | |
| SCHEMBL3842300 | 0.86 | LMNA (0.48) | METKDRRETKITPDGFRA | |
| SCHEMBL3842301 | 0.86 | LMNA (0.48) | METKDRRETKITPDGFRA | |
| SCHEMBL2934893 | 0.84 | MET (0.54) | METKDRRETKITPDGFRA | |
| SCHEMBL18256938 | 0.83 | MET (0.74) | METKDRRETKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |