Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529945 | 1.00 | CYP11B1 (0.49) | CYP11B1CYP11B2NPC1RAB9AMAP4K4 | |
| SCHEMBL29349922 | 0.87 | MEN1 (0.43) | CYP11B1CYP11B2NPC1RAB9AMAP4K4 | |
| SCHEMBL22529957 | 0.87 | MEN1 (0.43) | CYP11B1CYP11B2NPC1RAB9AMAP4K4 | |
| SCHEMBL22547106 | 0.83 | TSHR (0.47) | NPC1RAB9AMAP4K4MAPK1CYP1A2 | |
| SCHEMBL29350209 | 0.83 | TSHR (0.47) | NPC1RAB9AMAP4K4MAPK1CYP1A2 | |
| SCHEMBL22529946 | 0.82 | CYP11B1 (0.47) | CYP11B1CYP11B2NPC1RAB9AMAPK1 | |
| SCHEMBL29351920 | 0.80 | CYP11B1 (0.45) | CYP11B1CYP11B2NPC1RAB9AMAPK1 | |
| SCHEMBL22530938 | 0.80 | CYP11B1 (0.45) | CYP11B1CYP11B2NPC1RAB9AMAPK1 | |
| SCHEMBL18957388 | 0.79 | BCAT2 (0.50) | MAP4K4MAPK1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28718883 | 0.79 | CYP11B1 (0.52) | CYP11B1CYP11B2NPC1RAB9AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994001-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113966324-B | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-3953335-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Cellestia Biotech AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| CN-113966324-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2022-01-21 | — | — | CN | disclosed |