Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529957 | 1.00 | MEN1 (0.43) | MEN1KMT2AKDM4EMAP4K4GRM5 | |
| SCHEMBL29349924 | 0.87 | CYP11B1 (0.49) | MEN1KMT2AMAP4K4GRM5NPC1 | |
| SCHEMBL26140408 | 0.87 | MEN1 (0.39) | MEN1KMT2AKDM4EMAP4K4GRM5 | |
| SCHEMBL22529945 | 0.87 | CYP11B1 (0.49) | MEN1KMT2AMAP4K4GRM5NPC1 | |
| SCHEMBL22529903 | 0.85 | MEN1 (0.47) | MEN1KMT2AKDM4EMAP4K4NPC1 | |
| SCHEMBL29351760 | 0.85 | MEN1 (0.47) | MEN1KMT2AKDM4EMAP4K4NPC1 | |
| SCHEMBL29352030 | 0.82 | AURKA (0.38) | MEN1KMT2AKDM4EGRM5NPC1 | |
| SCHEMBL22529924 | 0.82 | AURKA (0.38) | MEN1KMT2AKDM4EGRM5NPC1 | |
| SCHEMBL22529954 | 0.81 | HSPB1 (0.47) | MEN1KMT2AKDM4EGRM5NPC1 | |
| SCHEMBL29351967 | 0.81 | HSPB1 (0.47) | MEN1KMT2AKDM4EGRM5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994001-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113966324-B | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-3953335-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Cellestia Biotech AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| CN-113966324-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2022-01-21 | — | — | CN | disclosed |