Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Phentolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 4/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 1.00 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.98 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.98 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 2/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.98 |
| ▸ | HRH1 | P35367 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | SCN1A | P35498 | 1/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | HTR2B | P41595 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phentolamine SCHEMBL9751780 | 0.99 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL29395338 | 0.99 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL5653 | 0.99 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL6431869 | 0.98 | ADRA1A (0.98) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL9057149 | 0.98 | ADRA1A (0.98) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL4343423 | 0.96 | ADRA1A (0.93) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL3764128 | 0.93 | CYP2D6 (0.98) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL28535560 | 0.93 | ADRA1A (0.89) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL3938445 | 0.92 | CYP2D6 (1.00) | ADRA1AADRA1DADRA1BMAPTADRA2A | |
| Phentolamine SCHEMBL40852 | 0.92 | CYP2D6 (1.00) | ADRA1AADRA1DADRA1BMAPTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 575 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119192085-A | Method for removing chloride ions in phentolamine | 江苏联环药业股份有限公司 | 2024-12-27 | — | — | CN | claimed |
| WO-2024028324-A1 | MOLECULES FOR THE PREVENTION AND TREATMENT OF NEUROMUSCULAR DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2024-02-08 | — | — | WO | claimed |
| CN-115417819-B | Preparation method of phentolamine mesylate | 安徽普利药业有限公司 | 2023-11-10 | — | — | CN | claimed |
| CN-115417819-A | Preparation method of phentolamine mesylate | 安徽普利药业有限公司 | 2022-12-02 | — | — | CN | claimed |
| WO-2017100324-A1 | COMBINATION THERAPY FOR TREATING FEMALE HYPOACTIVE SEXUAL DESIRE DISORDERS | REPROS THERAPEUTICS INC. (US) | 2017-06-15 | — | — | WO | claimed |
| US-20160257952-A1 | IDENTIFICATION OF STRUCTURALLY SIMILAR SMALL MOLECULES THAT ENHANCE THERAPEUTIC EXON SKIPPING | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-08 | — | — | US | claimed |
| CN-103408495-B | The synthesis technique of phentolamine mesilate | KUNSHAN SANYOU PHARMACEUTICAL MATERIAL CO., LTD. (CN) | 2016-02-24 | — | — | CN | claimed |
| CN-103408495-A | Synthesis process of phentolamine mesilate | KUNSHAN SANYOU PHARMACEUTICAL MATERIAL CO LTD | 2013-11-27 | — | — | CN | claimed |
| CN-101361725-B | External preparation containing phentolamine and preparation method thereof | UNIV FUDAN | 2011-05-18 | — | — | CN | claimed |
| US-20100311785-A1 | Combination Therapy For Modulating The Human Sexual Response | REPROS THERAPEUTICS INC. (US) | 2010-12-09 | — | — | US | claimed |
| EP-0767660-A1 | METHODS AND FORMULATIONS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1997-04-16 | — | — | EP | claimed |
| WO-1996033705-A1 | METHODS AND FORMULATIONS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1996-10-31 | — | — | WO | claimed |
| US-5565466-A | INCREASING BLOOD CIRCULATION BY ADMINISTERING A VASODILATOR AGENT | ZONAGEN, INC. (US) | 1996-10-15 | — | — | US | claimed |
| CN-1128950-A | Method for modulating human sexual response | ZONAGEN INC (US) | 1996-08-14 | — | — | CN | claimed |
| EP-0714300-A4 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN INC (US) | 1996-07-24 | — | — | EP | claimed |
| EP-0714300-A1 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995005172-A1 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1995-02-23 | — | — | WO | claimed |
| US-4659714-A | PROLONGATION WITH VASOCONSTRICTORS; REVERSAL WITH ADRENERGIC BLOCKING AGENTS | DENTSPLY, LTD. (GB) | 1987-04-21 | — | — | US | claimed |
| EP-0160191-A1 | Kit for treating mammals | Dentsply Limited (GB) | 1985-11-06 | — | — | EP | claimed |
| US-4532135-A | Treating renal damage by administering vasodilator having postsynaptic alpha-adrenoceptor blocking activity and antihyperlipidemic characteristics | EDWARDS K DAVID G | 1985-07-30 | — | — | US | claimed |