Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Phentolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 10/20 | 0.87 |
| ▸ | ADRA1D known ✓ | P25100 | 8/20 | 0.87 |
| ▸ | ADRA1B known ✓ | P35368 | 7/20 | 0.87 |
| ▸ | ADRA2A known ✓ | P08913 | 6/20 | 0.87 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.87 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | HTR1A | P08908 | 1/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | HTR2C | P28335 | 1/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phentolamine SCHEMBL3938445 | 1.00 | CYP2D6 (1.00) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL3764128 | 0.99 | CYP2D6 (0.98) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL5653 | 0.93 | ADRA1A (1.00) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL9751780 | 0.93 | ADRA1A (1.00) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL29395338 | 0.93 | ADRA1A (1.00) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL6431869 | 0.92 | ADRA1A (0.98) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL9057149 | 0.92 | ADRA1A (0.98) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL293522 | 0.92 | ADRA1A (1.00) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL28535560 | 0.90 | ADRA1A (0.89) | CYP2D6KDM4ECYP3A4TSHRNFKB1 | |
| Phentolamine SCHEMBL4343423 | 0.89 | ADRA1A (0.93) | CYP2D6KDM4ECYP3A4TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4049 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432401-B1 | — | — | None | — | — | US | claimed |
| EP-4721725-A2 | TREATMENT OF PRESBYOPIA AND MYDRIASIS WITH PHENTOLAMINE | Opus Genetics, Inc. (US) | 2026-04-08 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12576067-B2 | Methods and compositions for treatment of mydriasis | OPUS GENETICS, INC. (US) | 2026-03-17 | — | — | US | claimed |
| US-12576066-B2 | Methods and compositions for treatment of mydriasis | OPUS GENETICS, INC. (US) | 2026-03-17 | — | — | US | claimed |
| EP-3870170-B1 | TREATMENT OF PRESBYOPIA AND MYDRIASIS WITH PHENTOLAMINE | OPUS GENETICS INC (US) | 2026-02-25 | — | — | EP | claimed |
| US-20250262149-A1 | AQUEOUS OPHTHALMIC SOLUTIONS OF PHENTOLAMINE AND MEDICAL USES THEREOF | OCULARIS PHARMA, LLC | 2025-08-21 | — | — | US | claimed |
| US-20250248930-A1 | AQUEOUS OPHTHALMIC SOLUTIONS OF PHENTOLAMINE AND MEDICAL USES THEREOF | OCULARIS PHARMA, LLC | 2025-08-07 | — | — | US | claimed |
| US-20250248931-A1 | AQUEOUS OPHTHALMIC SOLUTIONS OF PHENTOLAMINE AND MEDICAL USES THEREOF | OCULARIS PHARMA, LLC | 2025-08-07 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| EP-0767660-A4 | METHODS AND FORMULATIONS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN INC (US) | 1997-08-27 | — | — | EP | claimed |
| EP-0767660-A1 | METHODS AND FORMULATIONS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1997-04-16 | — | — | EP | claimed |
| WO-1996033705-A1 | METHODS AND FORMULATIONS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1996-10-31 | — | — | WO | claimed |
| US-5565466-A | INCREASING BLOOD CIRCULATION BY ADMINISTERING A VASODILATOR AGENT | ZONAGEN, INC. (US) | 1996-10-15 | — | — | US | claimed |
| CN-1128950-A | Method for modulating human sexual response | ZONAGEN INC (US) | 1996-08-14 | — | — | CN | claimed |
| EP-0714300-A4 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN INC (US) | 1996-07-24 | — | — | EP | claimed |
| EP-0714300-A1 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995005172-A1 | METHODS FOR MODULATING THE HUMAN SEXUAL RESPONSE | ZONAGEN, INC. (US) | 1995-02-23 | — | — | WO | claimed |
| US-4659714-A | PROLONGATION WITH VASOCONSTRICTORS; REVERSAL WITH ADRENERGIC BLOCKING AGENTS | DENTSPLY, LTD. (GB) | 1987-04-21 | — | — | US | claimed |
| EP-0160191-A1 | Kit for treating mammals | Dentsply Limited (GB) | 1985-11-06 | — | — | EP | claimed |