Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | SCN4A | P35499 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529941 | 1.00 | SCN9A (0.41) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL22529924 | 0.86 | AURKA (0.38) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL29352030 | 0.86 | AURKA (0.38) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL21572280 | 0.82 | MEN1 (0.44) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL22529903 | 0.79 | MEN1 (0.47) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL29351760 | 0.79 | MEN1 (0.47) | SCN9AMEN1KMT2AKDM4EEGLN1 | |
| SCHEMBL22529968 | 0.77 | TTK (0.32) | MEN1KMT2A | |
| SCHEMBL22529973 | 0.76 | ADRB2 (0.45) | SCN9AMAPK14SLC6A4 | |
| SCHEMBL22530411 | 0.75 | ALDH1A1 (0.55) | SCN9AKDM4EALDH1A1 | |
| SCHEMBL22529970 | 0.74 | MEN1 (0.43) | SCN9AMEN1KMT2AKDM4EMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994001-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-113966324-B | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-117794536-A | Compounds for use in methods of treating autoimmune and inflammatory diseases | 塞莱斯蒂亚生物技术股份公司 | 2024-03-29 | — | — | CN | disclosed |
| EP-3953335-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | Cellestia Biotech AG (CH) | 2022-02-16 | — | — | EP | disclosed |
| CN-113966324-A | NOTCH signaling pathway inhibitors and their use in cancer treatment | 塞莱斯蒂亚生物技术股份公司 | 2022-01-21 | — | — | CN | disclosed |