Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.93 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.93 |
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | APEX1 | P27695 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL3265483 | 1.00 | — | — | |
| Choline SCHEMBL14957 | 0.96 | — | — | |
| Choline SCHEMBL29499824 | 0.96 | — | — | |
| Choline SCHEMBL28574484 | 0.96 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL1330530 | 0.96 | — | — | |
| Choline SCHEMBL9391204 | 0.96 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL2459999 | 0.96 | CYP3A4 (1.00) | CYP3A4SLC5A7MEN1KMT2ALMNA | |
| Choline SCHEMBL1332010 | 0.96 | — | — | |
| Choline SCHEMBL30612764 | 0.96 | — | — | |
| Choline SCHEMBL9422358 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113816991-A | Preparation method of choline calcium phosphochloride | 新乡拓新药业股份有限公司 | 2021-12-21 | — | — | CN | claimed |
| EP-2820028-A1 | A PROCESS FOR PREPARING PURE CITICOLINE (CDP-CHOLINE) | Frichem Private Limited (IN) | 2015-01-07 | — | — | EP | claimed |
| WO-2013128393-A1 | A PROCESS FOR PREPARING PURE CITICOLINE (CDP-CHOLINE) | FRICHEM PRIVATE LIMITED (IN) | 2013-09-06 | — | — | WO | claimed |
| EP-2229130-A2 | REMINERALIZING COMPOSITIONS AND METHODS | 3M Innovative Properties Company (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009076491-A2 | REMINERALIZING COMPOSITIONS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2009-06-18 | — | — | WO | claimed |
| CN-119955879-A | Method for synthesizing citicoline by biological enzyme | 拓新药业集团股份有限公司 | 2025-05-09 | — | — | CN | disclosed |
| WO-2025024123-A1 | NOVEL CITICOLINE DERIVATIVES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-01-30 | — | — | WO | disclosed |
| CN-113816991-B | Preparation method of choline calcium chloride phosphate | 拓新药业集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-113816991-B | Preparation method of choline calcium chloride phosphate | 拓新药业集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-113816991-A | Preparation method of choline calcium phosphochloride | 新乡拓新药业股份有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-113816991-A | Preparation method of choline calcium phosphochloride | 新乡拓新药业股份有限公司 | 2021-12-21 | — | — | CN | disclosed |
| EP-2820028-A1 | A PROCESS FOR PREPARING PURE CITICOLINE (CDP-CHOLINE) | Frichem Private Limited (IN) | 2015-01-07 | — | — | EP | disclosed |
| US-6926917-B2 | Dry pet food with increased palatability and method of production | NESTEC LTD. (CH) | 2005-08-09 | — | — | US | disclosed |
| WO-2004034812-A1 | DRY PET FOOD WITH INCREASED PALATABILITY AND METHOD OF PRODUCTION | NESTEC S.A. (CH) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004034811-A1 | INCREASED DENSITY PET FOOD PRODUCT AND METHOD OF PRODUCTION | NESTEC S.A. (CH) | 2004-04-29 | — | — | WO | disclosed |
| US-20040076718-A1 | Dry pet food with increased palatability and method of production | NESTEC, LTD. (CH) | 2004-04-22 | — | — | US | disclosed |
| US-20040076715-A1 | Increased density pet food product and method of production | NESTEC, LTD. (CH) | 2004-04-22 | — | — | US | disclosed |
| EP-0648495-B1 | Cation-complexed polysaccharides | HERCULES INC (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0648495-A2 | Cation-complexed polysaccharides | HERCULES INCORPORATED (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0323855-B1 | Pantethine as inhibitory agent of hepatic fibrosis | DAIICHI SEIYAKU CO (JP) | 1994-04-13 | — | — | EP | disclosed |