SCHEMBL29354544

SCHEMBL29354544

CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)[nH]n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 14/20 1.00
JAK2 O60674 8/20 1.00
AURKA O14965 4/20 1.00
JAK3 P52333 3/20 1.00
FGFR1 P11362 3/20 1.00
FLT3 P36888 3/20 1.00
PTK2 Q05397 3/20 1.00
NTRK3 Q16288 2/20 1.00
NTRK2 Q16620 2/20 1.00
BTK Q06187 2/20 1.00
ALK Q9UM73 2/20 1.00
RET P07949 2/20 1.00
TNK2 Q07912 2/20 1.00
LCK P06239 1/20 1.00
FYN P06241 1/20 1.00
IGF1R P08069 1/20 1.00
FLT1 P17948 1/20 1.00
LTK P29376 1/20 1.00
KDR P35968 1/20 1.00
CSNK1A1 P48729 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20626754 1.00 NTRK1 (1.00) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL18281508 0.84 NTRK1 (0.73) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL31060183 0.84 NTRK1 (0.73) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL588730 0.84 NTRK1 (0.73) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL29434985 0.84 NTRK1 (0.73) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL23217067 0.81 NTRK1 (0.80) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL29794572 0.81 NTRK1 (0.80) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL3340493 0.81 NTRK1 (0.80) NTRK1JAK2AURKAJAK3FGFR1
Phosphoric Acid SCHEMBL3041888 0.80 NTRK1 (0.66) NTRK1JAK2AURKAJAK3FGFR1
SCHEMBL3033142 0.80 NTRK1 (0.78) NTRK1JAK2AURKAJAK3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025216949-A1 METHODS FOR TREATING A TUMOR WITH ANTI-CDH6 ANTIBODY DRUG CONJUGATES ONCUSP THERAPEUTICS, INC. (US) 2025-10-16 WO claimed
US-20250129429-A1 GENE FUSIONS IN SARCOMA FOUNDATION MEDICINE, INC. (US) 2025-04-24 US claimed
US-12274699-B2 Methods of treating cholangiocarcinoma FOUNDATION MEDICINE, INC. (US) 2025-04-15 US claimed
EP-4423302-A2 NOVEL KINASE FUSIONS DETECTED BY LIQUID BIOPSY Foundation Medicine, Inc. (US) 2024-09-04 EP claimed
US-20240287616-A1 METHODS OF DETECTING NTRK FUSION PROTEINS STRATA ONCOLOGY INC (US) 2024-08-29 US claimed
CN-118414439-A Novel kinase fusion by liquid biopsy 基金会医学公司 2024-07-30 CN claimed
EP-4399330-A1 GENE FUSIONS IN SARCOMA Foundation Medicine, Inc. (US) 2024-07-17 EP claimed
US-20240228552-A9 NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING UNIVERSITY OF MASSACHUSETTS 2024-07-11 US claimed
US-20240132551-A1 NANOPORE TWEEZER APPROACH FOR PROTEIN KINASE ALLOSTERIC DRUG SCREENING UNIV MASSACHUSETTS (US) 2024-04-25 US claimed
EP-4355917-A1 METHODS OF DETECTING NTRK FUSION PROTEINS Strata Oncology, Inc. (US) 2024-04-24 EP claimed
US-11771698-B2 Methods of treating cholangiocarcinoma FOUNDATION MEDICINE, INC. (US) 2023-10-03 US claimed
EP-2914622-B1 NOVEL FUSION MOLECULES AND USES THEREOF FOUND MEDICINE INC (US) 2023-06-07 EP claimed
EP-2914621-B1 NOVEL NTRK1 FUSION MOLECULES AND USES THEREOF FOUND MEDICINE INC (US) 2023-06-07 EP claimed
WO-2023077104-A2 NOVEL KINASE FUSIONS DETECTED BY LIQUID BIOPSY FOUNDATION MEDICINE, INC. (US) 2023-05-04 WO claimed
WO-2023039539-A1 GENE FUSIONS IN SARCOMA FOUNDATION MEDICINE, INC. (US) 2023-03-16 WO claimed
US-11578372-B2 NTRK1 fusion molecules and uses thereof FOUNDATION MEDICINE, INC. (US) 2023-02-14 US claimed
WO-2022266551-A1 METHODS OF DETECTING NTRK FUSION PROTEINS Strata Oncology, Inc. (US) 2022-12-22 WO claimed
WO-2022225995-A1 METHODS AND SYSTEMS FOR GENE ALTERATION PREDICTION FROM PATHOLOGY SLIDE IMAGES F. HOFFMANN-LA ROCHE AG (CH) 2022-10-27 WO claimed
US-20220243280-A1 NTRK FUSION MOLECULES AND USES THEREOF FOUNDATION MEDICINE, INC. (US) 2022-08-04 US claimed
EP-3980563-A2 NTRK FUSION MOLECULES AND USES THEREOF Foundation Medicine, Inc. (US) 2022-04-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11578372-B2 NTRK1 fusion molecules and uses thereof NTRK1, NTRK3, NTRK2 NTRK1 1/4885JAK2 2623/4885AURKA 810/4885
US-20220243280-A1 NTRK FUSION MOLECULES AND USES THEREOF NTRK1, NTRK3, NTRK2 NTRK1 1/4885JAK2 2213/4885AURKA 1025/4885
US-12274699-B2 Methods of treating cholangiocarcinoma HCCS, PNLIP, LIPA NTRK1 2894/4885JAK2 1308/4885AURKA 766/4885
US-11771698-B2 Methods of treating cholangiocarcinoma HCCS, PNLIP, LIPA NTRK1 2894/4885JAK2 1308/4885AURKA 766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.