Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 10/20 | 0.33 |
| ▸ | CA2 | P00918 | 9/20 | 0.33 |
| ▸ | CA12 | O43570 | 7/20 | 0.33 |
| ▸ | CA9 | Q16790 | 7/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19742778 | 0.83 | L3MBTL1 (0.33) | CA1CA2 | |
| SCHEMBL19754003 | 0.82 | NR1H2 (0.34) | NR1H2 | |
| SCHEMBL29355972 | 0.79 | MAPK1 (0.35) | NR1H2GPR119CA1CA2CA12 | |
| SCHEMBL19742673 | 0.78 | PPIA (0.33) | NR1H2GPR119CA1CA2CA12 | |
| SCHEMBL29357526 | 0.78 | PPIA (0.33) | NR1H2GPR119CA1CA2CA12 | |
| SCHEMBL29357460 | 0.76 | KDM4A (0.41) | CA1CA2CA12CA9CA7 | |
| SCHEMBL4087871 | 0.74 | AKT1 (0.43) | NR1H2RORCALOX15 | |
| SCHEMBL25156176 | 0.74 | HDAC4 (0.46) | CA1CA12CA7CA14APLNR | |
| SCHEMBL30344367 | 0.74 | HDAC4 (0.46) | CA1CA12CA7CA14APLNR | |
| SCHEMBL29356515 | 0.73 | MAPT (0.41) | CA1CA2CA9CA7ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3474855-B1 | CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS INC (US) | 2022-01-26 | — | — | EP | disclosed |