Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13706046 | 0.77 | CYP2C19 (0.58) | GAACYP2C19PDE10APIK3CBHTT | |
| SCHEMBL29355937 | 0.77 | PIK3CA (0.46) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL30291577 | 0.74 | GAA (0.41) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL30291447 | 0.74 | GAA (0.43) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL30291553 | 0.74 | GAA (0.43) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL30291693 | 0.73 | PIK3CD (0.49) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL30291479 | 0.73 | PIK3CD (0.49) | GAACYP2C19PDE10APIK3CAPIK3CD | |
| SCHEMBL6843345 | 0.73 | GAA (0.59) | GAAPDE10APIK3CAPIK3CDLMNA | |
| SCHEMBL16834405 | 0.72 | GAA (0.50) | GAAPIK3CAPIK3CDPIK3CBLMNA | |
| SCHEMBL1515189 | 0.72 | HTR3E (0.66) | GAAPIK3CBKMT2AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |