Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291693 | 1.00 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3R1PIK3CBPRMT5 | |
| SCHEMBL30291577 | 0.86 | GAA (0.41) | PIK3CDPIK3CAPIK3R1PIK3CBPRMT5 | |
| SCHEMBL30291447 | 0.86 | GAA (0.43) | PIK3CDPIK3CAPIK3CBPRMT5WDR77 | |
| SCHEMBL30291553 | 0.86 | GAA (0.43) | PIK3CDPIK3CAPIK3CBPRMT5WDR77 | |
| SCHEMBL29355937 | 0.81 | PIK3CA (0.46) | PIK3CDPIK3CAPIK3R1PIK3CBGAA | |
| SCHEMBL6843345 | 0.75 | GAA (0.59) | PIK3CDPIK3CASMN1; SMN2GAAMAPK1 | |
| SCHEMBL16180015 | 0.75 | L3MBTL1 (0.45) | PIK3CDPIK3CAPIK3R1PIK3CBPRMT5 | |
| SCHEMBL25230198 | 0.75 | CYP11B2 (0.60) | PIK3CBPRMT5SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL13706046 | 0.73 | CYP2C19 (0.58) | PIK3CBSMN1; SMN2GAAMAPK1CYP2C19 | |
| SCHEMBL29356853 | 0.73 | GAA (0.43) | PIK3CDPIK3CAPIK3CBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230081390-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2023-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230081390-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | PIK3CD 154/4885PIK3CA 61/4885PIK3R1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.