Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29360309 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAPOLBPTGDR2ALDH1A1 | |
| SCHEMBL29358984 | 0.76 | LMNA (0.46) | SMN1; SMN2LMNAPOLBPTGDR2ALDH1A1 | |
| SCHEMBL22488568 | 0.76 | ESR2 (0.47) | SMN1; SMN2LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL7380124 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAPOLBPTGDR2ALDH1A1 | |
| SCHEMBL22468561 | 0.74 | DPP8 (0.33) | ESR1 | |
| SCHEMBL22468423 | 0.74 | DPP8 (0.33) | ESR1 | |
| SCHEMBL5814925 | 0.72 | LMNA (0.61) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL1444915 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL28484198 | 0.72 | LMNA (0.49) | SMN1; SMN2LMNAPOLBPTGDR2HRH2 | |
| SCHEMBL29358931 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPOLBPTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |