Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358931 | 0.82 | SMN1; SMN2 (0.49) | LMNAPOLBSMN1; SMN2PTGDR2GRM5 | |
| SCHEMBL29359100 | 0.76 | SMN1; SMN2 (0.46) | LMNAPOLBSMN1; SMN2PTGDR2HRH2 | |
| SCHEMBL22488309 | 0.76 | ESR2 (0.47) | LMNAPOLBSMN1; SMN2GRM5ALDH1A1 | |
| SCHEMBL7380124 | 0.76 | SMN1; SMN2 (0.54) | LMNAPOLBSMN1; SMN2PTGDR2HRH2 | |
| SCHEMBL7986424 | 0.75 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GRM5CYP3A4 | |
| SCHEMBL3697057 | 0.73 | LMNA (0.51) | LMNAPOLBSMN1; SMN2GRM5CYP3A4 | |
| SCHEMBL1444915 | 0.72 | SMN1; SMN2 (0.61) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL5814925 | 0.72 | LMNA (0.61) | LMNAPOLBSMN1; SMN2CYP1A2HRH2 | |
| SCHEMBL4752592 | 0.72 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2PTGDR2GRM5 | |
| SCHEMBL23062908 | 0.72 | LMNA (0.50) | LMNAPOLBSMN1; SMN2GRM5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |