SCHEMBL29359478

SCHEMBL29359478

O=Cc1cccc(F)c1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1574019 1.00 NFE2L2 (0.65)
SCHEMBL18472616 1.00
SCHEMBL24197 1.00
Hydrochloric Acid SCHEMBL29768617 0.98 NFE2L2 (0.62)
Ammonia Solution, Strong SCHEMBL27509053 0.98 NFE2L2 (0.62)
Hydrochloric Acid SCHEMBL29084496 0.98 NFE2L2 (0.62)
Cyclohexane SCHEMBL268585 0.93 NFE2L2 (0.58)
SCHEMBL17686281 0.91 NFE2L2 (0.64)
SCHEMBL3819301 0.87 TRIM24 (0.53)
Diethylamine SCHEMBL9301198 0.86 NFE2L2 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025081045-A9 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-12-26 WO disclosed
EP-4667056-A1 IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF Gilead Sciences, Inc. (US) 2025-12-24 EP disclosed
US-20250368625-A1 PIPERAZINES Grünenthal GmbH (DE) 2025-12-04 US disclosed
EP-4626891-A1 FUSED PYRIMIDINES AS MASP-2 INHIBITORS Omeros Corporation (US) 2025-10-08 EP disclosed
EP-4618985-A1 DUAL INHIBITORS OF SIGMA-1 RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE AND THEIR USE IN THE TREATMENT OF PAIN Universitat De Barcelona (ES) 2025-09-24 EP disclosed
EP-4612131-A1 NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY Cerevance, Inc. (US) 2025-09-10 EP disclosed
WO-2025122845-A1 IMIDAZOLE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS GENEP INC. (US) 2025-06-12 WO disclosed
US-12319664-B2 Herbicidally active 3-phenylisoxazoline-5-carboxamides of cyclopentenylcarboxylic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 2025-06-03 US disclosed
WO-2025081045-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-04-17 WO disclosed
US-12122764-B2 IKAROS zinc finger family degraders and uses thereof GILEAD SCIENCES, INC. (US) 2024-10-22 US disclosed
EP-4126848-A1 N-HETEROARYLALKYL-2-(HETEROCYCLYL AND HETEROCYCLYLMETHYL) ACETAMIDE DERIVATIVES AS SSTR4 AGONISTS Takeda Pharmaceutical Company Limited (JP) 2023-02-08 EP disclosed
EP-3743411-B1 HERBICIDAL 3-PHENYLISOXAZOLIN-5-CARBOXAMIDES OF CYCLOPENTENYL CARBOXYLIC ACID DERIVATIVES BAYER AG (DE) 2022-12-21 EP disclosed
WO-2022229405-A1 PYRIDINE-SULFONAMIDE DERIVATIVES AS SIGMA LIGANDS ACONDICIONAMIENTO TARRASENSE (ES) 2022-11-03 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-20220306591-A1 HERBICIDALLY ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES OF CYCLOPENTENYLCARBOXYLIC ACID DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2022-09-29 US disclosed
US-11453677-B2 Tricyclic compounds useful to treat orthomyxovirus infections NOVARTIS AG (CH) 2022-09-27 US disclosed
WO-2022174062-A1 METHODS AND COMPOSITIONS FOR MODULATING FGF ACTIVITY RECOVERY THERAPEUTICS, INC. (US) 2022-08-18 WO disclosed
EP-4038052-A2 PROSTAGLANDIN E2 (PGE2) EP4 RECEPTOR ANTAGONISTS Domain Therapeutics (FR) 2022-08-10 EP disclosed
US-20220227786-A1 Spiro Bicyclic Inhibitors Of Menin-MLL Interaction JANSSEN PHARMACEUTICA NV (BE) 2022-07-21 US disclosed
WO-2022019892-A1 THERAPEUTIC AGENTS AND USES THEREOF ANKH LIFE SCIENCES LIMITED (IE) 2022-01-27 WO disclosed