Sugi Predict

Sugi Predict / Compounds / Hmn-214

Hmn-214

Hmn-214

SCHEMBL29360540

COc1ccc(S(=O)(=O)N(C(C)=O)c2ccccc2C=Cc2cc[n+]([O-])cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PLK1

The experimentally established mechanism targets of Hmn-214. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 1/20 1.00
▸ STAT3 P40763 2/20 0.52
▸ SNCA P37840 3/20 0.41
▸ LMNA P02545 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ PKM P14618 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ ALOX12 P18054 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ NFE2L2 Q16236 6/20 0.39
▸ KEAP1 Q14145 5/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ RELA Q04206 2/20 0.38
▸ TUBB4A P04350 1/20 0.38
▸ TUBB P07437 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hmn-214 SCHEMBL5173713 1.00 MET (1.00) METSTAT3SNCALMNAALDH1A1
Hmn-214 SCHEMBL5173720 1.00 MET (1.00) METSTAT3SNCALMNAALDH1A1
Hmn-214 SCHEMBL5173985 0.92 MET (0.84) METSTAT3SNCALMNAALDH1A1
Hmn-214 SCHEMBL5174663 0.91 MET (0.83) METSTAT3SNCALMNAALDH1A1
Hmn-214 SCHEMBL6546098 0.90 MET (0.81) METSTAT3SNCALMNAALDH1A1
Hmn-214 SCHEMBL5174071 0.89 MET (0.80) METSTAT3SNCALMNAALDH1A1
SCHEMBL6951877 0.89 MET (0.80) METSTAT3SNCALMNAALDH1A1
SCHEMBL6951874 0.89 MET (0.80) METSTAT3SNCALMNAALDH1A1
SCHEMBL23277153 0.88 MET (0.79) METSTAT3LMNAALDH1A1MAPT
SCHEMBL6944793 0.87 MET (0.77) METSTAT3SNCALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605387-B2 Treatment of cancers using PI3 kinase isoform modulators SECURA BIO, INC. (US) 2026-04-21 — — US disclosed
US-20230293534-A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS SECURA BIO, INC. 2023-09-21 — — US disclosed
EP-4185279-A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS Secura Bio, Inc. (US) 2023-05-31 — — EP disclosed
WO-2022019920-A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS VERASTEM, INC. (US) 2022-01-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605387-B2 Treatment of cancers using PI3 kinase isoform modulators PIK3R5, PIK3R4, PIK3CD MET 1508/4885STAT3 809/4885SNCA 4336/4885
US-20230293534-A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS PIK3CA, MCL1, PI4KB MET 622/4885STAT3 352/4885SNCA 4802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.