Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hmn-214. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.81 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hmn-214 SCHEMBL5174071 | 0.99 | MET (0.80) | METSTAT3MAPTALDH1A1LMNA | |
| Hmn-214 SCHEMBL5173985 | 0.91 | MET (0.84) | METSTAT3MAPTALDH1A1LMNA | |
| Hmn-214 SCHEMBL5174663 | 0.91 | MET (0.83) | METSTAT3MAPTALDH1A1LMNA | |
| Hmn-214 SCHEMBL5173713 | 0.90 | MET (1.00) | METSTAT3MAPTALDH1A1LMNA | |
| Hmn-214 SCHEMBL29360540 | 0.90 | MET (1.00) | METSTAT3MAPTALDH1A1LMNA | |
| Hmn-214 SCHEMBL5173720 | 0.90 | MET (1.00) | METSTAT3MAPTALDH1A1LMNA | |
| SCHEMBL6546101 | 0.82 | MET (0.68) | METMAPTALDH1A1LMNAHPGD | |
| SCHEMBL6546090 | 0.82 | MET (0.68) | METMAPTALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL5174064 | 0.81 | MET (0.67) | METMAPTALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL5174079 | 0.81 | MET (0.67) | METMAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382335-A1 | MEDICINES | Nippon Shinyaku Co., Ltd. (JP) | 2004-01-21 | — | — | EP | claimed |