Sugi Predict

Sugi Predict / Compounds / SCHEMBL29360756

SCHEMBL29360756

SCHEMBL29360756

CC(C)(C)OC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 1/20 0.51
▸ HDAC4 P56524 3/20 0.51
▸ HDAC1 Q13547 2/20 0.51
▸ HDAC3 O15379 1/20 0.51
▸ HDAC7 Q8WUI4 1/20 0.51
▸ HDAC2 Q92769 1/20 0.51
▸ HDAC10 Q969S8 1/20 0.51
▸ HDAC11 Q96DB2 1/20 0.51
▸ HDAC8 Q9BY41 1/20 0.51
▸ HDAC6 Q9UBN7 1/20 0.51
▸ HDAC9 Q9UKV0 1/20 0.51
▸ HDAC5 Q9UQL6 1/20 0.51
▸ SIRT2 Q8IXJ6 9/20 0.49
▸ SIRT1 Q96EB6 9/20 0.49
▸ SIRT5 Q9NXA8 2/20 0.49
▸ SIRT3 Q9NTG7 2/20 0.48
▸ MEF2D Q14814 1/20 0.48
▸ RXFP1 Q9HBX9 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29360947 0.95 SIRT5 (0.47) MGLLHDAC4HDAC1HDAC3HDAC7
SCHEMBL29362656 0.90 SIRT2 (0.50) MGLLHDAC4HDAC1HDAC3HDAC7
SCHEMBL29357780 0.89 HDAC4 (0.52) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL22034400 0.89 SIRT5 (0.57) MGLLHDAC4HDAC1HDAC3HDAC7
SCHEMBL22034402 0.89 SIRT5 (0.57) MGLLHDAC4HDAC1HDAC3HDAC7
SCHEMBL29361609 0.89 SIRT2 (0.58) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL29358610 0.88 MMP8 (0.45) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL29359921 0.88 HDAC4 (0.49) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL29362934 0.88 CTNNB1 (0.54) HDAC8
SCHEMBL7400474 0.86 HDAC4 (0.51) HDAC4HDAC1HDAC3HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289848-A1 PEPTIDOMIMETIC INHIBITORS OF B-CATENIN/TCF PROTEIN-PROTEIN INTERACTION H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2025-09-18 — — US disclosed
US-12269899-B2 Peptidomimetic inhibitors of β-catenin/Tcf protein-protein interaction H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2025-04-08 — — US disclosed
US-20220024977-A1 PEPTIDOMIMETIC INHIBITORS OF B-CATENIN/TCF PROTEIN-PROTEIN INTERACTION H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. 2022-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250289848-A1 PEPTIDOMIMETIC INHIBITORS OF B-CATENIN/TCF PROTEIN-PROTEIN INTERACTION CTNNB1, CTNNBL1, CTNND1 MGLL 3593/4885HDAC4 2672/4885HDAC1 1549/4885
US-12269899-B2 Peptidomimetic inhibitors of β-catenin/Tcf protein-protein interaction CTNNB1, CTNNBL1, CTNND1 MGLL 3422/4885HDAC4 2510/4885HDAC1 1336/4885
US-20220024977-A1 PEPTIDOMIMETIC INHIBITORS OF B-CATENIN/TCF PROTEIN-PROTEIN INTERACTION CTNNB1, CTNNBL1, CTNND1 MGLL 3593/4885HDAC4 2672/4885HDAC1 1549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.