Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112406 | 0.97 | HPGD (0.57) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| SCHEMBL29441418 | 0.97 | HPGD (0.57) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| Phosphonic Acid SCHEMBL8955906 | 0.89 | HPGD (0.50) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| SCHEMBL279655 | 0.81 | ALDH1A1 (0.53) | HPGDSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| Toluic Acid SCHEMBL3179827 | 0.80 | ALDH1A1 (0.62) | HPGDSMN1; SMN2ERCC5FEN1ALDH1A1 | |
| SCHEMBL29087835 | 0.79 | MYC (0.50) | HPGDSMN1; SMN2TYK2ALDH1A1KDM4E | |
| SCHEMBL166603 | 0.79 | HPGD (0.54) | HPGDSMN1; SMN2ERCC5FEN1ALDH1A1 | |
| SCHEMBL29425530 | 0.79 | HPGD (0.54) | HPGDSMN1; SMN2ERCC5FEN1ALDH1A1 | |
| SCHEMBL333141 | 0.79 | CYP3A4 (0.55) | HPGDSMN1; SMN2ERCC5FEN1ALDH1A1 | |
| SCHEMBL29387256 | 0.79 | CYP3A4 (0.55) | HPGDSMN1; SMN2ERCC5FEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220023450-A1 | BONE MARROW-, RETICULOENDOTHELIAL SYSTEM-, AND/OR LYMPH NODE-TARGETED RADIOLABELED LIPOSOMES AND METHODS OF THEIR DIAGNOSTIC AND THERAPEUTIC USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220023450-A1 | BONE MARROW-, RETICULOENDOTHELIAL SYSTEM-, AND/OR LYMPH NODE-TARGETED RADIOLABELED LIPOSOMES AND METHODS OF THEIR DIAGNOSTIC AND THERAPEUTIC USE | KIT, LIPA, CTSA | HPGD 4118/4885SMN1; SMN2 2719/4885TYK2 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.