Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441418 | 0.91 | HPGD (0.57) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| SCHEMBL112406 | 0.91 | HPGD (0.57) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| Bromide SCHEMBL29360866 | 0.89 | HPGD (0.55) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| O-Xylene SCHEMBL30657210 | 0.78 | TSHR (0.62) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| O-Xylene SCHEMBL125242 | 0.78 | TSHR (0.62) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| O-Xylene SCHEMBL28408327 | 0.78 | TSHR (0.62) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL28739353 | 0.76 | HPGD (0.47) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| SCHEMBL279655 | 0.75 | ALDH1A1 (0.53) | HPGDSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL734717 | 0.75 | HPGD (0.50) | HPGDSMN1; SMN2TYK2ERCC5FEN1 | |
| SCHEMBL29087835 | 0.74 | MYC (0.50) | HPGDSMN1; SMN2TYK2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538978-A | NUCLEOSIDE PHOSPHORYLASE INHIBITORS AS IMMUNOSUPPRESSANTS, ANTILYMPHOMA, ANTILEUKEMIA, VIRICIDES AND ANTIPROTOZOA AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5527803-A | IMMUNOSUPPRESSANTS, PHOSPHORYLASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5494912-A | 9-purinyl phosphonic acid derivitives for treating gout | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0465297-B1 | 9-Purinyl phosphonic acid derivatives | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0465297-A1 | 9-Purinyl phosphonic acid derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |