Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.73 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.73 |
| ▸ | NNMT | P40261 | 1/20 | 0.57 |
| ▸ | OXTR | P30559 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870306 | 1.00 | MKNK1 (0.73) | MKNK1MKNK2NNMTOXTRPDGFRB | |
| SCHEMBL30280631 | 0.86 | MKNK1 (0.73) | MKNK1MKNK2NNMTOXTRPDGFRB | |
| SCHEMBL12641872 | 0.86 | MKNK1 (0.73) | MKNK1MKNK2NNMTOXTRPDGFRB | |
| SCHEMBL29757598 | 0.85 | NNMT (0.70) | MKNK1MKNK2NNMTOXTRMAPT | |
| SCHEMBL185291 | 0.85 | NNMT (0.70) | MKNK1MKNK2NNMTOXTRMAPT | |
| SCHEMBL1869662 | 0.85 | MKNK1 (0.59) | MKNK1MKNK2NNMTOXTRMAPT | |
| SCHEMBL2945799 | 0.85 | MKNK1 (0.71) | MKNK1MKNK2NNMTOXTRHSD17B1 | |
| SCHEMBL2224592 | 0.84 | MAP4K4 (0.77) | MKNK1MKNK2MAP4K4 | |
| SCHEMBL703607 | 0.84 | NNMT (0.68) | MKNK1MKNK2NNMTOXTRMAPT | |
| SCHEMBL2039201 | 0.83 | MAPT (0.76) | MKNK1MKNK2PDGFRBPDGFRARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773249-B | Compounds, pharmaceutical compositions and methods for treating inflammatory diseases | 艾匹克治疗公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-113980001-B | Pyrazolol-pyridazinone coupling compound, pharmaceutical composition thereof and application of pyrazolol-pyridazinone coupling compound in medicines | 贵州医科大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-114773249-A | Compounds, pharmaceutical compositions and methods for treating inflammatory diseases | 艾匹克治疗公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113980001-A | Pyrazole alcohol-pyridazinone coupling compound, pharmaceutical composition thereof and application thereof in medicines | 贵州医科大学 | 2022-01-28 | — | — | CN | disclosed |