SCHEMBL185291

SCHEMBL185291

COc1ccc(C(=O)O)cn1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NNMT P40261 2/20 0.70
MAPT P10636 1/20 0.68
L3MBTL1 Q9Y468 2/20 0.57
MKNK1 Q9BUB5 1/20 0.57
MKNK2 Q9HBH9 1/20 0.57
P4HA1 P13674 2/20 0.55
P4HTM Q9NXG6 2/20 0.55
MIF P14174 1/20 0.53
GABRP O00591 1/20 0.52
GABRD O14764 1/20 0.52
GABRA1 P14867 1/20 0.52
GABRB1 P18505 1/20 0.52
GABRG2 P18507 1/20 0.52
GABRB3 P28472 1/20 0.52
GABRA5 P31644 1/20 0.52
GABRA3 P34903 1/20 0.52
GABRA2 P47869 1/20 0.52
GABRB2 P47870 1/20 0.52
GABRA4 P48169 1/20 0.52
GABRE P78334 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29757598 1.00 NNMT (0.70) NNMTMAPTL3MBTL1MKNK1MKNK2
SCHEMBL703607 0.98 NNMT (0.68) NNMTMAPTL3MBTL1MKNK1MKNK2
SCHEMBL1869662 0.88 MKNK1 (0.59) NNMTMAPTL3MBTL1MKNK1MKNK2
SCHEMBL21836535 0.87 NNMT (0.73) NNMTMAPTL3MBTL1MKNK1MKNK2
SCHEMBL18228074 0.86 NNMT (0.72) NNMTMAPTMKNK1MKNK2OXTR
SCHEMBL1870306 0.85 MKNK1 (0.73) NNMTMAPTMKNK1MKNK2OXTR
SCHEMBL29365356 0.85 MKNK1 (0.73) NNMTMAPTMKNK1MKNK2OXTR
SCHEMBL105066 0.84 NNMT (0.70) NNMTMAPTMKNK1MKNK2OXTR
SCHEMBL29514668 0.84 NNMT (0.70) NNMTMAPTMKNK1MKNK2OXTR
SCHEMBL22529883 0.83 CA1 (0.55) NNMTMAPTMKNK1MKNK2OXTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 617 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431432-A Andrographolide diester derivative, preparation method and application 西北农林科技大学 2025-02-14 CN claimed
CN-111295382-B Bridged bicyclic compounds as farnesyl ester X receptor modulators 百时美施贵宝公司 2024-02-02 CN claimed
CN-113912592-A Honokiol dihydrofuran ester derivative, preparation method and application thereof 西北农林科技大学 2022-01-11 CN claimed
CN-110317204-A Pyrazolopyrimidinonefor derivative and its preparation method and application 安徽农业大学 2019-10-11 CN claimed
CN-105063833-B Short fiber composite spinning device and spinning method thereof 宁夏荣昌绒业集团有限公司 2017-05-10 CN claimed
CN-105063833-A Short fiber composite spinning device and spinning method thereof NINGXIA RONGCHANG CASHMERE GROUP CO LTD 2015-11-18 CN claimed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
EP-4737449-A1 P53-Y220C SELECTIVE SMALL-MOLECULAR REACTIVATOR COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF Changchun Genescience Pharmaceutical Co., Ltd. (CN) 2026-05-06 EP disclosed
EP-4713306-A1 NOVEL TRACER FOR THE IN VIVO DETECTION OF THE AGGREGATION OF ALPHA-SYNUCLEIN Stichting Amsterdam UMC (NL) 2026-03-25 EP disclosed
US-20260078123-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF SHANGHAI DAIDAI INVESTMENT CONSULTING CO., LTD (CN) 2026-03-19 US disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
US-12552796-B2 EED inhibitor, and preparation method therefor and use thereof JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2026-02-17 US disclosed
WO-1991009856-A1 PHARMACEUTICALLY ACTIVE OXAZOLE COMPOUNDS BEECHAM GROUP PLC (GB) 1991-07-11 WO disclosed
US-5028617-A Heteroarylethanol-pyridylalkylamines for controlling animal growth BAYER AKTIENGESELLSCHAFT (DE) 1991-07-02 US disclosed
EP-0379928-A2 Aryl- and heteroarylethanol-pyridylalkylamines, process for their preparation and their use as performance stimulators by animals and as anti-adipositas agent BAYER AG (DE) 1990-08-01 EP disclosed
EP-0163855-B1 NITROMETHYLENE DERIVATIVES, INTERMEDIATES, AND PROCESS FOR THEIR PREPARATION AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-06-21 EP disclosed
EP-0258430-A1 NEMATIC LIQUID CRYSTAL PHASES MERCK PATENT GmbH (DE) 1988-03-09 EP disclosed
WO-1987005316-A1 NEMATIC LIQUID CRYSTAL PHASES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1987-09-11 WO disclosed
US-4642308-A ANTICONVULSANTS, ANXIOLYTIC AGENTS, ANTIEPILEPTIC AGENTS, HYPNOTICS, MUSCLE RELAXANTS RHONE-POULENC SANTE (FR) 1987-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078123-A1 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF NR3C1, CXCR1, CCR1 NNMT 1612/4885MAPT 4833/4885L3MBTL1 1977/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH NNMT 4025/4885MAPT 3782/4885L3MBTL1 1163/4885
US-12552796-B2 EED inhibitor, and preparation method therefor and use thereof HSD11B1, CYP4A11, CYP8B1 NNMT 2362/4885MAPT 970/4885L3MBTL1 3405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.