Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.46 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | CTSE | P14091 | 2/20 | 0.43 |
| ▸ | PGC | P20142 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934499 | 0.87 | REN (0.49) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL13404557 | 0.85 | REN (0.48) | RENCTSDCTSEPGCCHRM5 | |
| SCHEMBL2938316 | 0.78 | REN (0.39) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL13404516 | 0.76 | REN (0.59) | RENCTSDCTSEPGCKCNH2 | |
| SCHEMBL3083589 | 0.75 | REN (0.55) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL2931136 | 0.75 | REN (0.54) | RENCTSDCTSEPGC | |
| SCHEMBL2931137 | 0.75 | REN (0.54) | RENCTSDCTSEPGC | |
| SCHEMBL2935535 | 0.72 | REN (0.51) | RENCTSDCTSEPGCKCNH2 | |
| SCHEMBL2935537 | 0.72 | REN (0.51) | RENCTSDCTSEPGCKCNH2 | |
| SCHEMBL2929364 | 0.71 | REN (0.52) | RENCTSDCTSEPGCSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | claimed |