Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.48 |
| ▸ | CTSE | P14091 | 2/20 | 0.48 |
| ▸ | PGC | P20142 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938316 | 0.90 | REN (0.39) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL3083589 | 0.89 | REN (0.55) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL2936615 | 0.87 | REN (0.46) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL13404516 | 0.85 | REN (0.59) | RENCTSDCTSEPGCHTR1A | |
| SCHEMBL3073914 | 0.80 | REN (0.44) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL3064636 | 0.79 | REN (0.45) | RENCTSDCTSEPGCMRGPRX4 | |
| SCHEMBL3084349 | 0.78 | REN (0.42) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL3085347 | 0.77 | REN (0.54) | RENCTSDCTSEPGCSLC6A4 | |
| SCHEMBL13404515 | 0.76 | REN (0.49) | RENCTSDCTSEPGCHTR1A | |
| SCHEMBL13404557 | 0.76 | REN (0.48) | RENCTSDCTSEPGCHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | claimed |