Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918932 | 0.96 | NPC1 (0.47) | NPC1RAB9ALIPGPTPN1ALDH1A1 | |
| SCHEMBL3213632 | 0.90 | ALDH1A1 (0.47) | NPC1RAB9APTPN1ALDH1A1LMNA | |
| SCHEMBL3224621 | 0.90 | PTPN1 (0.47) | LIPGPTPN1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL3224733 | 0.89 | NPC1 (0.39) | NPC1RAB9ALIPGPTPN1ALDH1A1 | |
| SCHEMBL4557598 | 0.87 | NPC1 (0.49) | NPC1RAB9APTPN1ALDH1A1LMNA | |
| SCHEMBL3218066 | 0.84 | KDM4E (0.52) | LIPGPTPN1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL4782790 | 0.82 | MEN1 (0.42) | NPC1RAB9ALIPGPTPN1NAMPT | |
| SCHEMBL3224729 | 0.81 | PTPN1 (0.37) | LIPGPTPN1ALDH1A1NAMPT | |
| SCHEMBL3205299 | 0.81 | MEN1 (0.48) | RAB9ALIPGPTPN1ALDH1A1NAMPT | |
| SCHEMBL2933875 | 0.80 | PTPN1 (0.45) | LIPGPTPN1MTNR1AMTNR1BLIPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227245-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | Novartis AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068689-A2 | COMBINATION OF PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND HUMAN GROWTH HORMONE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |