Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213632 | 0.96 | ALDH1A1 (0.47) | NPC1RAB9ANAMPTALDH1A1LMNA | |
| SCHEMBL3205299 | 0.94 | MEN1 (0.48) | RAB9ANAMPTALDH1A1MAPTMEN1 | |
| SCHEMBL3918932 | 0.91 | NPC1 (0.47) | NPC1RAB9ANAMPTALDH1A1LMNA | |
| SCHEMBL2936685 | 0.87 | NPC1 (0.43) | NPC1RAB9ANAMPTALDH1A1LMNA | |
| SCHEMBL4782790 | 0.84 | MEN1 (0.42) | NPC1RAB9ANAMPTMEN1GAA | |
| SCHEMBL3224733 | 0.83 | NPC1 (0.39) | NPC1RAB9ANAMPTALDH1A1LMNA | |
| SCHEMBL3759377 | 0.81 | PTPN1 (0.46) | NPC1RAB9ANAMPTMAPTMEN1 | |
| SCHEMBL3218066 | 0.80 | KDM4E (0.52) | ALDH1A1LMNAMAPTPTPN1SMN1; SMN2 | |
| SCHEMBL3915822 | 0.80 | ABCB1 (0.43) | RAB9ANAMPTALDH1A1LMNAMEN1 | |
| SCHEMBL3215930 | 0.79 | PTPN1 (0.56) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |