Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.67 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.67 |
| ▸ | NAMPT | P43490 | 1/20 | 0.62 |
| ▸ | TACR3 | P29371 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101155 | 0.85 | ROCK2 (0.73) | TAS1R3TAS1R1NAMPTROCK2ROCK1 | |
| SCHEMBL4490832 | 0.85 | TAS1R3 (0.60) | TAS1R3TAS1R1NAMPTTACR3ROCK2 | |
| SCHEMBL7723793 | 0.83 | TAS1R3 (0.56) | TAS1R3TAS1R1NAMPTTACR3ROCK2 | |
| SCHEMBL7723790 | 0.83 | TAS1R3 (0.56) | TAS1R3TAS1R1NAMPTTACR3ROCK2 | |
| SCHEMBL792022 | 0.83 | TAS1R3 (0.56) | TAS1R3TAS1R1NAMPTTACR3ROCK2 | |
| SCHEMBL1139148 | 0.83 | MEN1 (0.53) | TAS1R3TAS1R1NAMPTTACR3ROCK2 | |
| SCHEMBL14198862 | 0.83 | MEN1 (0.63) | TAS1R3TAS1R1TACR3ROCK2ROCK1 | |
| SCHEMBL12226572 | 0.83 | MEN1 (0.63) | TAS1R3TAS1R1TACR3ROCK2ROCK1 | |
| SCHEMBL27781112 | 0.83 | MEN1 (0.63) | TAS1R3TAS1R1TACR3ROCK2ROCK1 | |
| SCHEMBL15716619 | 0.82 | TAS1R3 (0.54) | TAS1R3TAS1R1NAMPTTACR3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109983016-B | Pyrimido [5,4-b ] indolizine or pyrimido [5,4-b ] pyridine compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2022-02-01 | — | — | CN | disclosed |