Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936827 | 1.00 | IGF1R (0.45) | IGF1RCTSSPTGS2LMNAMAPK1 | |
| SCHEMBL6175175 | 0.78 | IGF1R (0.36) | IGF1RCTSSPTGS2LMNAMAPK1 | |
| SCHEMBL2936799 | 0.77 | IGF1R (0.67) | IGF1RCTSS | |
| SCHEMBL2999392 | 0.77 | IGF1R (0.67) | IGF1RCTSS | |
| SCHEMBL2936802 | 0.77 | IGF1R (0.67) | IGF1RCTSS | |
| SCHEMBL2936828 | 0.76 | IGF1R (0.58) | IGF1RCTSSPTGS2LMNAMAPK1 | |
| SCHEMBL2937942 | 0.75 | IGF1R (0.64) | IGF1RCTSSLMNAMAPK1HTT | |
| SCHEMBL17558422 | 0.75 | IGF1R (0.35) | IGF1R | |
| SCHEMBL17558373 | 0.75 | IGF1R (0.35) | IGF1R | |
| SCHEMBL6173750 | 0.73 | KMT2A (0.39) | IGF1RPTGS2LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |