Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 6/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 3/20 | 0.47 |
| ▸ | CCNH | P51946 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377063 | 1.00 | TTK (0.51) | TTKJAK2JAK3MARK3PTK2 | |
| SCHEMBL29371334 | 0.90 | JAK2 (0.56) | TTKJAK2JAK3PTK2CDK2 | |
| SCHEMBL18376246 | 0.90 | JAK2 (0.56) | TTKJAK2JAK3PTK2CDK2 | |
| SCHEMBL18376662 | 0.89 | TTK (0.51) | TTKJAK2JAK3CDK4BRD4 | |
| SCHEMBL30859695 | 0.89 | TTK (0.65) | TTKJAK2JAK3PTK2CDK2 | |
| SCHEMBL18376252 | 0.89 | TTK (0.65) | TTKJAK2JAK3PTK2CDK2 | |
| SCHEMBL18376790 | 0.87 | TTK (0.50) | TTKJAK2CDK4BRD4JUN | |
| SCHEMBL18377065 | 0.87 | PTK2 (0.55) | TTKJAK2JAK3PTK2CDK4 | |
| SCHEMBL29368482 | 0.87 | PTK2 (0.55) | TTKJAK2JAK3PTK2CDK4 | |
| SCHEMBL29371949 | 0.87 | TTK (0.50) | TTKJAK2CDK4BRD4JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |