Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5946896 | 0.81 | KMT2A (0.57) | ALDH1A1SMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL23462473 | 0.81 | MEN1 (0.67) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24439606 | 0.79 | MEN1 (0.65) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2480756 | 0.78 | GAA (0.71) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL22532970 | 0.76 | GAA (0.68) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6397367 | 0.75 | HTR2A (0.49) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| 4-Nitrophenyl Dimethylcarbamate SCHEMBL8648791 | 0.75 | GAA (1.00) | GAAALDH1A1SMN1; SMN2KMT2AACHE | |
| Hydrochloric Acid SCHEMBL10720860 | 0.74 | GAA (0.50) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL10720865 | 0.74 | GAA (0.50) | GAAALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4028412 | 0.74 | GAA (0.64) | GAAALDH1A1SMN1; SMN2KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807646-B2 | 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2023-11-07 | — | — | US | disclosed |
| US-20220033397-A1 | PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LTD (GB) | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033397-A1 | PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | USP19, USP16, USP18 | GAA 133/4885ALDH1A1 3271/4885SMN1; SMN2 337/4885 |
| US-11807646-B2 | 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19) | USP19, USP16, USP18 | GAA 248/4885ALDH1A1 1427/4885SMN1; SMN2 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.