Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 16/20 | 0.77 |
| ▸ | MET | P08581 | 15/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885888 | 0.97 | INSR (0.81) | INSRMETALK | |
| SCHEMBL885999 | 0.87 | MET (1.00) | INSRMETALK | |
| SCHEMBL886548 | 0.86 | MET (0.79) | INSRMETALK | |
| SCHEMBL884896 | 0.85 | MET (0.63) | INSRMETALK | |
| SCHEMBL886541 | 0.84 | INSR (1.00) | INSRMETALK | |
| SCHEMBL886578 | 0.83 | INSR (0.71) | INSRMETALK | |
| SCHEMBL886602 | 0.83 | INSR (0.76) | INSRMETALK | |
| SCHEMBL886478 | 0.82 | INSR (0.70) | INSRMETALK | |
| SCHEMBL885902 | 0.81 | INSR (0.69) | INSRMETALK | |
| SCHEMBL885981 | 0.81 | MET (0.88) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |