Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 11/20 | 1.00 |
| ▸ | BMPR1A | P36894 | 11/20 | 1.00 |
| ▸ | ACVRL1 | P37023 | 11/20 | 1.00 |
| ▸ | ACVR1 | Q04771 | 11/20 | 1.00 |
| ▸ | TGFBR1 | P36897 | 10/20 | 1.00 |
| ▸ | MERTK | Q12866 | 5/20 | 0.64 |
| ▸ | AXL | P30530 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | CCNC | P24863 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19807056 | 1.00 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806978 | 0.91 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL29370244 | 0.91 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806979 | 0.91 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19806970 | 0.89 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL29372986 | 0.89 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| Trifluoroacetic Acid SCHEMBL29373477 | 0.86 | BMPR1B (0.88) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19807032 | 0.85 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL29370395 | 0.85 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL20995196 | 0.82 | BMPR1B (0.71) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114014844-B | Aminopyridine derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-114014844-A | Aminopyridine derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2022-02-08 | — | — | CN | disclosed |