Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.53 |
| ▸ | YES1 | P07947 | 4/20 | 0.53 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376821 | 1.00 | SRC (0.53) | SRCYES1AIMP2BRAFBRD4 | |
| SCHEMBL29370829 | 0.92 | BRAF (0.55) | SRCYES1BRAFBRD4JAK2 | |
| SCHEMBL18377042 | 0.92 | BRAF (0.55) | SRCYES1BRAFBRD4JAK2 | |
| SCHEMBL18376823 | 0.87 | SRC (0.53) | SRCYES1BRAFJAK2JAK3 | |
| SCHEMBL29371097 | 0.87 | SRC (0.53) | SRCYES1BRAFJAK2JAK3 | |
| SCHEMBL18377066 | 0.87 | BRAF (0.60) | SRCYES1BRAFBRD4JAK2 | |
| SCHEMBL29371925 | 0.87 | BRAF (0.60) | SRCYES1BRAFBRD4JAK2 | |
| SCHEMBL29370809 | 0.84 | PIK3CG (0.60) | KDREGFRRIPK2CLK4PTK2 | |
| SCHEMBL18377040 | 0.84 | PIK3CG (0.60) | KDREGFRRIPK2CLK4PTK2 | |
| SCHEMBL18376820 | 0.84 | JAK2 (0.55) | SRCBRAFJAK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |