Nerinetide

Nerinetide

SCHEMBL29371548

CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ TFPI P10646 1/20 0.65
▸ VIPR1 P32241 4/20 0.60
▸ VIPR2 P41587 6/20 0.58
▸ KEAP1 Q14145 1/20 0.57
▸ GLP1R P43220 5/20 0.57
▸ ECE1 P42892 1/20 0.57
▸ MUS81 Q96NY9 1/20 0.57
▸ PTH1R Q03431 1/20 0.56
▸ CCKBR P32239 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30220503 0.97 TFPI (0.66) TFPIVIPR1VIPR2KEAP1GLP1R
SCHEMBL30974623 0.95 TFPI (0.63) TFPIVIPR1VIPR2KEAP1GLP1R
SCHEMBL30165222 0.93 TFPI (0.61) TFPIVIPR1VIPR2KEAP1
SCHEMBL30658586 0.93 TFPI (0.67) TFPIVIPR1VIPR2GLP1RECE1
SCHEMBL29702365 0.90 TFPI (0.78) TFPIVIPR1VIPR2GLP1R
SCHEMBL29489273 0.90 TFPI (0.73) TFPIVIPR1VIPR2GLP1RECE1
SCHEMBL29519384 0.90 TFPI (0.68) TFPIVIPR1VIPR2GLP1RECE1
SCHEMBL30176447 0.89 VIPR1 (0.65) TFPIVIPR1VIPR2GLP1RECE1
SCHEMBL30629356 0.89 VIPR1 (0.71) TFPIVIPR1VIPR2KEAP1GLP1R
SCHEMBL30695558 0.89 TFPI (0.78) TFPIVIPR1VIPR2GLP1RECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240301003-A1 PLASMIN-RESISTANT PEPTIDES FOR IMPROVED THERAPEUTIC INDEX NONO INC. (CA) 2024-09-12 — — US claimed
EP-3757134-B1 CHLORIDE SALT OF TAT-NR2B9C NONO INC (CA) 2024-03-06 — — EP claimed
US-11911438-B2 Chloride salt of TAT-NR2B9C NONO INC. (CA) 2024-02-27 — — US claimed
US-11878044-B2 Combination therapy for ischemia NONO INC. (CA) 2024-01-23 — — US claimed
EP-4274596-A1 PLASMIN-RESISTANT PEPTIDES FOR IMPROVED THERAPEUTIC INDEX NoNO Inc. (CA) 2023-11-15 — — EP claimed
CN-116897051-A Plasmin peptides for increasing therapeutic index 诺诺公司 2023-10-17 — — CN claimed
US-20230285504-A1 INHIBITION OF REPERFUSION INJURY WITH A PSD-95 INHIBITOR NONO INC. (CA) 2023-09-14 — — US claimed
US-20230139826-A1 COMBINATION TREATMENT OF STROKE WITH PLASMIN-CLEAVABLE PSD-95 INHIBITOR AND REPERFUSION NONO INC. (CA) 2023-05-04 — — US claimed
US-20230055441-A1 PLASMIN-RESISTANT PEPTIDES FOR TREATING STROKE AND RELATED CONDITIONS NONO INC. (CA) 2023-02-23 — — US claimed
EP-2334315-B1 AGENTS AND METHODS FOR TREATMENT OF PAIN NONO INC (CA) 2023-01-18 — — EP claimed
EP-4106818-A1 INHIBITION OF REPERFUSION INJURY WITH A PSD-95 INHIBITOR NoNO Inc. (CA) 2022-12-28 — — EP claimed
EP-4087880-A1 PLASMIN-RESISTANT PEPTIDES FOR TREATING STROKE AND RELATED CONDITIONS NoNO Inc. (CA) 2022-11-16 — — EP claimed
WO-2022150655-A1 PLASMIN-RESISTANT PEPTIDES FOR IMPROVED THERAPEUTIC INDEX NONO INC. (CA) 2022-07-14 — — WO claimed
US-20220175879-A1 THERAPY FOR SUBARACHNOID HEMORRHAGE AND ISCHEMIA NONO INC. (CA) 2022-06-09 — — US claimed
US-20220175880-A1 CHLORIDE SALT OF TAT-NR2B9C NONO INC. (CA) 2022-06-09 — — US claimed
US-20220106362-A1 SELENIUM-BASED THERAPIES UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE 2022-04-07 — — US claimed
US-20220096383-A1 LYOPHILIZED FORMULATION OF TAT-NR2B9C WITH ACETYLATION SCAVENGER NONO INC. (CA) 2022-03-31 — — US claimed
US-11266714-B2 Chloride salt of TAT-NR2B9C NONO INC. (CA) 2022-03-08 — — US claimed
EP-3427748-B1 COMBINATION THERAPY FOR ISCHEMIA NONO INC (CA) 2022-03-02 — — EP claimed
CN-114057895-A Chloride salt of TAT-NR2B9c 诺诺公司 2022-02-18 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11266714-B2 Chloride salt of TAT-NR2B9C CHRNA9, SCN9A, GRIN2C TFPI 1322/4885VIPR1 2502/4885VIPR2 2625/4885
US-20220096383-A1 LYOPHILIZED FORMULATION OF TAT-NR2B9C WITH ACETYLATION SCAVENGER TREH, TBCA, GALC TFPI 827/4885VIPR1 2970/4885VIPR2 3177/4885
US-11911438-B2 Chloride salt of TAT-NR2B9C CHRNA9, SCN9A, GRIN2C TFPI 1322/4885VIPR1 2502/4885VIPR2 2625/4885
US-11878044-B2 Combination therapy for ischemia PSD, DAPK2, FABP7 TFPI 75/4885VIPR1 881/4885VIPR2 556/4885
US-20240301003-A1 PLASMIN-RESISTANT PEPTIDES FOR IMPROVED THERAPEUTIC INDEX DAO, DNPEP, DDO TFPI 175/4885VIPR1 914/4885VIPR2 1367/4885
US-20220175879-A1 THERAPY FOR SUBARACHNOID HEMORRHAGE AND ISCHEMIA PSD, FABP7, DAPK2 TFPI 155/4885VIPR1 1757/4885VIPR2 1293/4885
US-20220175880-A1 CHLORIDE SALT OF TAT-NR2B9C CHRNA9, SCN9A, GRIN2C TFPI 1322/4885VIPR1 2502/4885VIPR2 2625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback