Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.72 |
| ▸ | CTSD | P07339 | 2/20 | 0.51 |
| ▸ | CTSE | P14091 | 2/20 | 0.51 |
| ▸ | PGC | P20142 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | RNF4 | P78317 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934829 | 1.00 | REN (0.72) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2930675 | 0.86 | REN (0.77) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2930677 | 0.86 | REN (0.77) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2934086 | 0.85 | REN (0.74) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2934085 | 0.85 | REN (0.74) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2931030 | 0.84 | REN (0.77) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2931369 | 0.84 | REN (1.00) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2931630 | 0.84 | REN (1.00) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2931370 | 0.84 | REN (1.00) | RENCTSDCTSEPGCSLC6A2 | |
| SCHEMBL2931031 | 0.84 | REN (0.77) | RENCTSDCTSEPGCSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | claimed |
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | claimed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | claimed |
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |