SCHEMBL29375789

SCHEMBL29375789

COc1ccc2nc3cc(Cl)ccc3c(NCCNc3c4ccc(Cl)cc4nc4ccc(OC)cc34)c2c1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.83
MEN1 O00255 1/20 0.77
KMT2A Q03164 1/20 0.77
TDP1 Q9NUW8 1/20 0.77
MBNL1 Q9NR56 1/20 0.76
GSR P00390 7/20 0.70
KDM4E B2RXH2 1/20 0.63
PHLPP2 Q6ZVD8 2/20 0.61
CYP19A1 P11511 1/20 0.61
NPC1 O15118 1/20 0.58
USP2 O75604 1/20 0.58
PRNP P04156 1/20 0.58
CHRM2 P08172 1/20 0.58
CHRM4 P08173 1/20 0.58
ABCB1 P08183 1/20 0.58
HTR1A P08908 1/20 0.58
CHRM5 P08912 1/20 0.58
ADRA2A P08913 1/20 0.58
CHRM1 P11229 1/20 0.58
ADRA2B P18089 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7875793 1.00 ADORA2A (0.83) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL7869225 0.96 MBNL1 (0.81) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL7880398 0.96 MEN1 (0.79) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL20087027 0.95 MBNL1 (0.80) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL20087077 0.95 MBNL1 (0.80) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL20087053 0.95 MBNL1 (0.80) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL23795497 0.94 MBNL1 (0.75) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL7874381 0.94 ADORA2A (0.78) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL22420449 0.94 ADORA2A (0.74) ADORA2AMEN1KMT2ATDP1MBNL1
SCHEMBL23904131 0.93 MBNL1 (0.77) ADORA2AMEN1KMT2ATDP1MBNL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4168054-A1 CONJUGATED AND LABELLED APELIN, PREPARATION AND USES THEREOF Universite d'Aix Marseille (FR) 2023-04-26 EP claimed
EP-4709718-A1 6-SUBSTITUTED-3-PHENYL-ISOINDOLIN-1-ONES AS CBL-B INHIBITORS SELECTIVE OVER C-CBL Genentech Inc. (US) 2026-03-18 EP disclosed
WO-2025104679-A1 PROCESSES FOR MAKING INTERMEDIATES FOR ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-05-22 WO disclosed
EP-4508109-A1 COMPOSITION, URETHANE PREPOLYMER, AND RELATED METHODS AND USES Dow Silicones Corporation (US) 2025-02-19 EP disclosed
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 WO disclosed
EP-4413009-A1 PREPARATION OF AMINO-FUNCTIONAL ORGANOSILICON COMPOUNDS Dow Global Technologies LLC (US) 2024-08-14 EP disclosed
EP-4413010-A1 PREPARATION OF IMINE-FUNCTIONAL ORGANOSILICON COMPOUNDS AND PRIMARY AMINO-FUNCTIONAL ORGANOSILICON COMPOUNDS Dow Global Technologies LLC (US) 2024-08-14 EP disclosed
CN-111065744-B Method for producing chiral amines 威妥有限公司 2024-05-03 CN disclosed
EP-4323358-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER Hotspot Therapeutics, Inc. (US) 2024-02-21 EP disclosed
WO-2023200684-A1 COMPOSITION, URETHANE PREPOLYMER, AND RELATED METHODS AND USES DOW SILICONES CORPORATION (US) 2023-10-19 WO disclosed
EP-4180424-A1 SUBSTITUTED PYRAZOLES AS HUMAN PLASMA KALLIKREIN INHIBITORS BioCryst Pharmaceuticals, Inc. (US) 2023-05-17 EP disclosed
CN-116134068-A Polymerization process 牛津大学科技创新有限公司 2023-05-16 CN disclosed
WO-2023060153-A1 PREPARATION OF AMINO-FUNCTIONAL ORGANOSILICON COMPOUNDS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-04-13 WO disclosed
WO-2023060154-A1 PREPARATION OF IMINE-FUNCTIONAL ORGANOSILICON COMPOUNDS AND PRIMARY AMINO-FUNCTIONAL ORGANOSILICON COMPOUNDS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-04-13 WO disclosed
EP-4153591-A1 METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS Recurium IP Holdings, LLC (US) 2023-03-29 EP disclosed
WO-2022256525-A1 COBALT CATALYSTS CONTAINING \"SMART\"OR\"TASK SPECIFIC\"ANIONS THE TEXAS A&M UNIVERSITY SYSTEM (US) 2022-12-08 WO disclosed
CN-115260203-A Quinoxalino-phenazine luminescent material and application thereof 浙江工业大学 2022-11-01 CN disclosed
WO-2022221704-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER HOTSPOT THERAPEUTICS, INC. (US) 2022-10-20 WO disclosed
US-20220041634-A1 Three-Dimensional Organic Sandwich Chirality and Its Synthetic Assembly TEXAS TECH UNIVERSITY SYSTEM 2022-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220041634-A1 Three-Dimensional Organic Sandwich Chirality and Its Synthetic Assembly WNT3, CTNNB1, ORC3 ADORA2A 4500/4885MEN1 1644/4885KMT2A 1359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.