SCHEMBL2937597

SCHEMBL2937597

Cc1cccn1CCCOc1ccc(-n2cc(C(=O)N3CCOCC3)cn2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 14/20 0.67
CHRM2 P08172 1/20 0.48
CHRM1 P11229 1/20 0.48
ADRA2C P18825 1/20 0.48
CHRM3 P20309 1/20 0.48
DRD4 P21917 1/20 0.48
SLC6A2 P23975 1/20 0.48
HRH2 P25021 1/20 0.48
SLC6A4 P31645 1/20 0.48
HRH1 P35367 1/20 0.48
SLC6A3 Q01959 1/20 0.48
HRH4 Q9H3N8 1/20 0.48
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
ALDH1A1 P00352 2/20 0.42
GAA P10253 1/20 0.42
NPC1 O15118 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2943744 0.97 HRH3 (0.64) HRH3CHRM2CHRM1ADRA2CCHRM3
SCHEMBL1179240 0.84 HRH3 (0.73) HRH3CHRM2CHRM1ADRA2CCHRM3
SCHEMBL2937460 0.83 HRH3 (0.45) HRH3HRH2HRH1ALDH1A1GAA
SCHEMBL1179508 0.83 HRH3 (0.71) HRH3CHRM2CHRM1ADRA2CCHRM3
Hydrochloric Acid SCHEMBL2938655 0.83 HPGDS (0.49) HRH3ALDH1A1NPC1RAB9AKDM4E
SCHEMBL2936786 0.83 MAPKAPK2 (0.47) HRH3ALDH1A1GAANPC1RAB9A
SCHEMBL1179145 0.81 HRH3 (0.74) HRH3CHRM2CHRM1ADRA2CCHRM3
SCHEMBL1179531 0.80 HRH3 (0.68) HRH3CHRM2CHRM1ADRA2CCHRM3
SCHEMBL1179419 0.80 HRH3 (1.00) HRH3CHRM2CHRM1ADRA2CCHRM3
SCHEMBL15372527 0.80 HRH3 (1.00) HRH3CHRM2CHRM1ADRA2CCHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2221298-A1 PHENYLPYRAZOLE DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD (JP) 2010-08-25 EP disclosed