Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937597 | 0.97 | HRH3 (0.67) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL1179240 | 0.81 | HRH3 (0.73) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL2937460 | 0.81 | HRH3 (0.45) | HRH3HRH2HRH1NPC1RAB9A | |
| SCHEMBL1178701 | 0.81 | HRH3 (0.95) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL1179508 | 0.81 | HRH3 (0.71) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL2936786 | 0.80 | MAPKAPK2 (0.47) | HRH3NPC1RAB9AHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2938655 | 0.80 | HPGDS (0.49) | HRH3NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1179145 | 0.79 | HRH3 (0.74) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL15372527 | 0.78 | HRH3 (1.00) | HRH3CHRM2CHRM1ADRA2CCHRM3 | |
| SCHEMBL1179531 | 0.78 | HRH3 (0.68) | HRH3CHRM2CHRM1ADRA2CCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2221298-A1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-08-25 | — | — | EP | disclosed |