Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16102370 | 0.83 | NOTUM (0.58) | RXRAGRIN1GRIN2BL3MBTL1POLB | |
| SCHEMBL29378354 | 0.83 | NOTUM (0.47) | RXRAGRIN1GRIN2BNOTUM | |
| SCHEMBL31588577 | 0.78 | NOTUM (0.45) | NOTUM | |
| SCHEMBL6276669 | 0.73 | KMT2A (0.54) | POLBNOTUMSCN5A | |
| SCHEMBL31465996 | 0.72 | HTT (0.47) | RXRAGRIN1GRIN2BL3MBTL1POLB | |
| SCHEMBL29378534 | 0.72 | MAPT (0.50) | NOTUMCYP19A1 | |
| SCHEMBL29379236 | 0.71 | NOTUM (0.47) | L3MBTL1NOTUMMAOA | |
| SCHEMBL16556797 | 0.70 | NOTUM (0.53) | RXRAGRIN1GRIN2BL3MBTL1POLB | |
| SCHEMBL28266420 | 0.69 | RXRA (0.43) | RXRAGRIN1GRIN2BL3MBTL1POLB | |
| SCHEMBL8087729 | 0.69 | RXRA (0.40) | RXRAGRIN1GRIN2BL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041578-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | CRBN, CUL4B, UBQLN1 | RXRA 2289/4885GRIN1 1627/4885GRIN2B 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.