Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 9/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.36 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.36 |
| ▸ | TAF1 | P21675 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | ATAD2B | Q9ULI0 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29702280 | 0.83 | LRRK2 (0.40) | BRD4LRRK2CREBBPBRD9BRD7 | |
| SCHEMBL29702235 | 0.83 | RAF1 (0.40) | BRD4CREBBPSOS1ADORA2AADORA1 | |
| SCHEMBL29702343 | 0.78 | BRD4 (0.43) | BRD4CREBBPADORA2AADORA1ACVR1 | |
| SCHEMBL29702360 | 0.77 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL26100427 | 0.77 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL25213735 | 0.75 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL29380274 | 0.75 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL17076663 | 0.72 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL31083319 | 0.72 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL29702221 | 0.71 | LRRK2 (0.48) | LRRK2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621186-A | Heterocyclic compounds as modulators of RAS signaling pathway | 上海维申医药有限公司 | 2022-06-14 | — | — | CN | disclosed |